Clipping

Products that enable the clipping of grids and their manipulation and ensure the quality of the clipping.

 

Autogrid Tweezers (traditional)

NanoSoft offers the Autogrid Tweezers that accompany the autogrid clipping and cassette loading station from Thermo Fisher Scientific for their autoloader-based cryo-EM workflow.  Our Autogrid Tweezers are designed to have the same geometry as the version from Thermo Fisher, such that cartridges/autogrids are handled and loaded into the cassette in the same way. This includes a notched feature in the tip of the tweezers that provides a datum against which the autogrid can rest, ensuring that the autogrid is placed centered in the cassette slot and at the correct depth. 

Furthermore, our version of the Autogrid Tweezers has the removable tips attached with a specialty adhesive that ensures that the tips remain aligned appropriately (while allowing for disassembly if needed).  We offer this item with equal or better performance than the Thermo Fisher part, but at a far more generous price. 

SKU: 23021002
Price: $595
Sale Price: Now $395

Reverse Action Autogrid Tweezers

 
SKU: 23021004
Price: $395

NanoSoft has developed a version of the Autogrid Tweezers that maintains the same tip geometry as the traditional Autogrid Tweezers (with notched tip to safely cradle autogrids and ensuring that autogrids are placed centered in the cassette slot and at the correct depth), but with a reverse-action handle. The reverse-action handle ensures that the tweezers hold the autogrid securely in their natural state, making orientation and manipulation steps with the autogrid easier, and ensuring that the valuable clipped grid cannot be dropped.

 

Autogrid Inspection Tool

SKU: 18021002
Price: $85

High demand for cryo-EM imaging time at core facilities has resulted in ever-growing throughput of samples through high-end, autoloader-based EM's.  Often the person loading autogrids into the autoloader cassette did not clip the grids that they are loading.  Inserting a poorly clipped autogrid into the cassette could lead to it popping out of the cassette while in the autoloader and significant EM downtime.

The autogrid inspection tool is a low-cost way of performing a last autogrid inspection step prior to loading them into the cassette.  It is placed into a grid box spot in the cassette loading station and will remain there securely due to the spring-loaded detent on the side of the tool.  Autogrids can be placed in the groove of the Autogrid inspection tool and quickly flipped back and forth to check that the grid is securely clipped.  It provides a final, low-cost check to help ensure only well-clipped grids are loaded into the autoloader, saving the potential disaster of a poorly clipped grid coming undone in the autoloader and weeks of downtime.